Tubulo-papillary renal cell carcinoma in a captive ocelot (Leopardus pardalis)
A 12 years old captive ocelot (Leopardus pardalis) was diagnosed with a 2.6x2.2x1.6 cms mass on the cranial pole of the right kidney. No other macroscopic changes were observed during necropsy. The mass was processed by standard Hematoxilin & Eosin staining. Periodic Acid-Schiff (PAS)stainin...
| Autores Principales: | Romero-Vega, L. Mario, Hagnauer, Isabel, Alfaro-Alarcon, Alejandro |
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| Formato: | Conferencia |
| Idioma: | Inglés |
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American College of Veterinary Pathologists
2022
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| Materias: | |
| Acceso en línea: |
http://hdl.handle.net/11056/24362 |
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RepoUNACR24362 |
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RepoUNACR243622022-11-21T20:17:56Z Tubulo-papillary renal cell carcinoma in a captive ocelot (Leopardus pardalis) Romero-Vega, L. Mario Hagnauer, Isabel Alfaro-Alarcon, Alejandro CANCER RIÑONES LEOPARDUS PARDALIS FELINOS PATOLOGÍA ANIMAL ANIMAL PATOLOGY FELINE KIDNEYS A 12 years old captive ocelot (Leopardus pardalis) was diagnosed with a 2.6x2.2x1.6 cms mass on the cranial pole of the right kidney. No other macroscopic changes were observed during necropsy. The mass was processed by standard Hematoxilin & Eosin staining. Periodic Acid-Schiff (PAS)staining was also performed. The tissue was analyzed for the following markers by immunohistochemistry: WT1, CK Ae1/A3, CK19, CK 7, Vimentin , Melan-1, and HMB45. Only vimentin had a positive stain. Under microscopic examination, the mass was surrounded by a fibrous pseudocapsule and compressed the adjacent normal renal. The tumoral cells are small cuboidal epithelial cells arranged in a single layer. The tissue cells have lightly eosinophilic cytoplasm, a rounded nucleus, and no mitoses. The epithelial cells grow in a papillary pattern which contains pseudo-rosettes in their lumen. Some of these pseudo-rosettes contain a PAS positive material, most likely Tamm-Horsfall protein. The stroma was also PASpositive. The number of pseudorosettes varies from one to several in each tubule. Based on this finding, the tumor was classified as a tubulo-papillary renal cell carcinoma. Although this neoplasia is well described in domestic cats, it is rarely reported in wild felids. To our best knowledge, this is the first renal carcinoma reported in the Pardalis genera, which includes 13 new world felids. Its occurrence in an Ocelot is valuable since neoplasias in this specie are rarely reported in Latin America. A un ocelote (Leopardus pardalis) de 12 años en cautividad se le diagnosticó con una masa de 2,6x2,2x1,6 cms en el polo craneal del riñón derecho. No se observaron otros cambios macroscópicos durante necropsia. La masa fue procesada mediante tinción estándar de Hematoxilina y Eosina. También se realizó la tinción de ácido periódico-Schiff (PAS). El tejido fue analizado para los siguientes marcadores por inmunohistoquímica: WT1, CK Ae1/A3, CK19, CK 7, Vimentina , Melan-1 y HMB45. Sólo la vimentina tuvo una tinción positiva. En examen microscópico, la masa estaba rodeada por una pseudocápsula y comprimía el riñón normal adyacente. Las células tumorales son pequeñas células epiteliales cuboidales dispuestas en una capa única. Las células del tejido tienen un citoplasma ligeramente eosinófilo, un núcleo redondeado y sin mitosis. Las células epiteliales crecen en un patrón papilar que contiene pseudo-rosetas en su lumen. Algunas de estas pseudo-rosetas contienen un material PAS positivo, probablemente la proteína Tamm-Horsfall. El estroma también es PAS positivo. El número de pseudorosetas varía de una a varios en cada túbulo. Sobre la base de este hallazgo, el tumor fue clasificado como un carcinoma tubulopapilar de células renales. Aunque esta neoplasia está bien descrita en los gatos domésticos, rara vez en los felinos salvajes. Hasta donde sabemos, éste es el primer carcinoma renal descrito en el género Pardalis, que incluye 13 félidos del nuevo mundo. Su aparición en un Ocelote es valiosa ya que neoplasias en esta especie son raramente reportadas en América Latina. Universidad Nacional, Costa Rica Escuela de Medicina Veterinaria 2022-11-21T20:14:42Z 2022-11-21T20:14:42Z 2022-11-14 http://purl.org/coar/resource_type/c_6670 N15 http://hdl.handle.net/11056/24362 eng Acceso abierto http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf American College of Veterinary Pathologists ACVP/ASVCP Annual Meeting, 2022 |
| institution |
Universidad Nacional de Costa Rica |
| collection |
Repositorio UNA-Costa Rica |
| language |
Inglés |
| topic |
CANCER RIÑONES LEOPARDUS PARDALIS FELINOS PATOLOGÍA ANIMAL ANIMAL PATOLOGY FELINE KIDNEYS |
| spellingShingle |
CANCER RIÑONES LEOPARDUS PARDALIS FELINOS PATOLOGÍA ANIMAL ANIMAL PATOLOGY FELINE KIDNEYS Romero-Vega, L. Mario Hagnauer, Isabel Alfaro-Alarcon, Alejandro Tubulo-papillary renal cell carcinoma in a captive ocelot (Leopardus pardalis) |
| description |
A 12 years old captive ocelot (Leopardus pardalis) was diagnosed
with a 2.6x2.2x1.6 cms mass on the cranial pole of the right
kidney. No other macroscopic changes were observed during
necropsy. The mass was processed by standard Hematoxilin &
Eosin staining. Periodic Acid-Schiff (PAS)staining was also
performed. The tissue was analyzed for the following markers by
immunohistochemistry: WT1, CK Ae1/A3, CK19, CK 7, Vimentin ,
Melan-1, and HMB45. Only vimentin had a positive stain. Under
microscopic examination, the mass was surrounded by a fibrous
pseudocapsule and compressed the adjacent normal renal. The
tumoral cells are small cuboidal epithelial cells arranged in a
single layer. The tissue cells have lightly eosinophilic cytoplasm, a
rounded nucleus, and no mitoses. The epithelial cells grow in a
papillary pattern which contains pseudo-rosettes in their lumen.
Some of these pseudo-rosettes contain a PAS positive material,
most likely Tamm-Horsfall protein. The stroma was also PASpositive. The number of pseudorosettes varies from one to
several in each tubule. Based on this finding, the tumor was
classified as a tubulo-papillary renal cell carcinoma. Although
this neoplasia is well described in domestic cats, it is rarely
reported in wild felids. To our best knowledge, this is the first
renal carcinoma reported in the Pardalis genera, which includes
13 new world felids. Its occurrence in an Ocelot is valuable since
neoplasias in this specie are rarely reported in Latin America. |
| format |
Conferencia |
| author |
Romero-Vega, L. Mario Hagnauer, Isabel Alfaro-Alarcon, Alejandro |
| author_sort |
Romero-Vega, L. Mario |
| title |
Tubulo-papillary renal cell carcinoma in a captive ocelot (Leopardus pardalis) |
| title_short |
Tubulo-papillary renal cell carcinoma in a captive ocelot (Leopardus pardalis) |
| title_full |
Tubulo-papillary renal cell carcinoma in a captive ocelot (Leopardus pardalis) |
| title_fullStr |
Tubulo-papillary renal cell carcinoma in a captive ocelot (Leopardus pardalis) |
| title_full_unstemmed |
Tubulo-papillary renal cell carcinoma in a captive ocelot (Leopardus pardalis) |
| title_sort |
tubulo-papillary renal cell carcinoma in a captive ocelot (leopardus pardalis) |
| publisher |
American College of Veterinary Pathologists |
| publishDate |
2022 |
| url |
http://hdl.handle.net/11056/24362 |
| _version_ |
1796096364991479808 |
| score |
12.233033 |