Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica
Background: Animal studies have shown that both deficiency and excess manganese (Mn) may result in decreased fetal size and weight, but human studies have reported inconsistent results. Methods: We examined the association of blood and hair Mn concentrations measured at different times during pre...
| Autores Principales: | Mora, Ana María, van Wendel de Joode, Berna, Mergler, Donna, Córdoba, Leonel, Cano, Camilo, Quesada, Rosario, Smith, Donald R, Menezes-Filho, José A., Eskenazi, Brenda |
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Elsevier
2016
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http://hdl.handle.net/11056/13214 https://doi.org/10.1016/j.envres.2014.10.011 |
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RepoUNACR132142023-08-09T18:17:02Z Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica Mora, Ana María van Wendel de Joode, Berna Mergler, Donna Córdoba, Leonel Cano, Camilo Quesada, Rosario Smith, Donald R Menezes-Filho, José A. Eskenazi, Brenda ISA PROGRAMA INFANTES Y SALUD AMBIENTAL SALUD PÚBLICA SUSTANCIAS TÓXICAS RIESGOS PARA LA SALUD PUBLIC HEALTH TOXIC SUBSTANCES HEALTH RISKS Background: Animal studies have shown that both deficiency and excess manganese (Mn) may result in decreased fetal size and weight, but human studies have reported inconsistent results. Methods: We examined the association of blood and hair Mn concentrations measured at different times during pregnancy with fetal growth among term births and length of gestation in a cohort of 380 mother–infant pairs living near banana plantations aerially sprayed with Mn-containing fungicides in Costa Rica. We used linear regression and generalized additive models to test for linear and nonlinear associations Results: Mean (7 SD) blood Mn concentration was 24.476.6 μg/L and geometric mean (geometric SD) hair Mn concentration was 1.8 (3.2) μg/g. Hair Mn concentrations during the second and third trimesters of gestation were positively related to infant chest circumference (β for 10-fold increase¼0.62 cm; 95% CI: 0.16, 1.08; and β¼0.55 cm; 95% CI: 0.16, 1.26, respectively). Similarly, average maternal hair Mn concentrations during pregnancy were associated with increased chest circumference (β for 10-fold increase¼1.19 cm; 95% CI: 0.43, 1.95) in infants whose mothers did not have gestational anemia, but not in infants of mothers who had gestational anemia (β¼0.39 cm; 95% CI: 0.32, 1.10; pINT¼0.14). All these associations were linear. Blood Mn concentrations did not show consistent linear nor nonlinear relationships with any of the birth outcomes Conclusions: Mn plays an important role in fetal development, but the extent to which environmental exposures may cause adverse health effects to the developing fetus is not well understood. Among women living near banana plantations in Costa Rica, we did not observe linear or nonlinear associations of Mn concentrations with lowered birth weight or head circumference, as reported in previous studies. However, we did find positive linear associations between maternal hair Mn concentrations during pregnancy and infant chest circunference. Antecedentes: Los estudios en animales han demostrado que tanto la deficiencia como el exceso de manganeso (Mn) pueden dar lugar a disminuyó el tamaño y el peso del feto, pero los estudios en humanos han reportado resultados inconsistentes. Métodos: Examinamos la asociación de las concentraciones de Mn en la sangre y en el cabello medidas en diferentes momentos durante el embarazo con crecimiento fetal entre partos a término y duración de la gestación en una cohorte de 380 parejas de madre e hijo que viven cerca de plantaciones de plátanos rociadas desde el aire con fungicidas que contienen Mn en Costa Rica. Usamos regresión lineal y modelos aditivos generalizados para probar las asociaciones lineales y no lineales Resultados: La media (7 SD) de la concentración de Mn en sangre fue de 24.476.6 μg/L y la media geométrica (SD geométrica) La concentración de Mn en el cabello era de 1,8 (3,2) μg/g. Las concentraciones de Mn del pelo durante el segundo y tercer trimestre de la gestación se relacionaron positivamente con la circunferencia torácica del lactante (β por 10 veces increase¼0.62 cm; 95% IC: 0,16, 1,08; y β¼0.55 cm; IC del 95%: 0,16, 1,26, respectivamente). De manera similar, el promedio de pelo materno Mn durante el embarazo se asociaron con un aumento de la circunferencia del pecho (β por 10 veces más increase¼1.19 cm; 95% CI: 0.43, 1.95) en bebés cuyas madres no tenían anemia gestacional, pero no en los bebés de madres que tenían anemia gestacional (β¼0.39 cm; 95% CI: 0.32, 1.10; pINT¼0.14). Todos estos las asociaciones eran lineales. Las concentraciones de Mn en la sangre no mostraron relaciones lineales ni no lineales consistentes con ninguno de los resultados de nacimiento Conclusiones: El Mn juega un papel importante en el desarrollo fetal, pero la medida en que el medio ambiente La exposición puede causar efectos adversos para la salud del feto en desarrollo no se comprende bien. Entre las mujeres que viven cerca de las plantaciones de banano en Costa Rica, no observamos asociaciones lineales o no lineales de concentraciones de Mn con un menor peso al nacer o con un menor perímetro cefálico, como se ha informado en estudios anteriores. Sin embargo, encontramos asociaciones lineales positivas entre las concentraciones de Mn en el cabello de la madre durante el embarazo y la circunferencia torácica del bebé. Universidad Nacional, Costa Rica University of California, Berkeley Université du Québec à Montréal, Pavillon des sciences University of California, Santa Cruz Federal University of Bahia, Av. Barão de Jeremoabo s/n Campus Universitário de Ondina 2016-10-13T21:10:43Z 2016-10-13T21:10:43Z 2015 http://purl.org/coar/resource_type/c_6501 http://hdl.handle.net/11056/13214 https://doi.org/10.1016/j.envres.2014.10.011 en Acceso embargado http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Environmental Research vol.136 47-56 2015 |
| institution |
Universidad Nacional de Costa Rica |
| collection |
Repositorio UNA-Costa Rica |
| language |
Inglés |
| topic |
ISA PROGRAMA INFANTES Y SALUD AMBIENTAL SALUD PÚBLICA SUSTANCIAS TÓXICAS RIESGOS PARA LA SALUD PUBLIC HEALTH TOXIC SUBSTANCES HEALTH RISKS |
| spellingShingle |
ISA PROGRAMA INFANTES Y SALUD AMBIENTAL SALUD PÚBLICA SUSTANCIAS TÓXICAS RIESGOS PARA LA SALUD PUBLIC HEALTH TOXIC SUBSTANCES HEALTH RISKS Mora, Ana María van Wendel de Joode, Berna Mergler, Donna Córdoba, Leonel Cano, Camilo Quesada, Rosario Smith, Donald R Menezes-Filho, José A. Eskenazi, Brenda Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica |
| description |
Background: Animal studies have shown that both deficiency and excess manganese (Mn) may result in
decreased fetal size and weight, but human studies have reported inconsistent results.
Methods: We examined the association of blood and hair Mn concentrations measured at different times
during pregnancy with fetal growth among term births and length of gestation in a cohort of 380 mother–infant pairs living near banana plantations aerially sprayed with Mn-containing fungicides in Costa
Rica. We used linear regression and generalized additive models to test for linear and nonlinear associations
Results: Mean (7 SD) blood Mn concentration was 24.476.6 μg/L and geometric mean (geometric SD)
hair Mn concentration was 1.8 (3.2) μg/g. Hair Mn concentrations during the second and third trimesters
of gestation were positively related to infant chest circumference (β for 10-fold increase¼0.62 cm; 95%
CI: 0.16, 1.08; and β¼0.55 cm; 95% CI: 0.16, 1.26, respectively). Similarly, average maternal hair Mn
concentrations during pregnancy were associated with increased chest circumference (β for 10-fold
increase¼1.19 cm; 95% CI: 0.43, 1.95) in infants whose mothers did not have gestational anemia, but not
in infants of mothers who had gestational anemia (β¼0.39 cm; 95% CI: 0.32, 1.10; pINT¼0.14). All these
associations were linear. Blood Mn concentrations did not show consistent linear nor nonlinear relationships with any of the birth outcomes
Conclusions: Mn plays an important role in fetal development, but the extent to which environmental
exposures may cause adverse health effects to the developing fetus is not well understood. Among
women living near banana plantations in Costa Rica, we did not observe linear or nonlinear associations
of Mn concentrations with lowered birth weight or head circumference, as reported in previous studies.
However, we did find positive linear associations between maternal hair Mn concentrations during
pregnancy and infant chest circunference. |
| format |
Artículo |
| author |
Mora, Ana María van Wendel de Joode, Berna Mergler, Donna Córdoba, Leonel Cano, Camilo Quesada, Rosario Smith, Donald R Menezes-Filho, José A. Eskenazi, Brenda |
| author_sort |
Mora, Ana María |
| title |
Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica |
| title_short |
Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica |
| title_full |
Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica |
| title_fullStr |
Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica |
| title_full_unstemmed |
Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica |
| title_sort |
maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the isa cohort in costa rica |
| publisher |
Elsevier |
| publishDate |
2016 |
| url |
http://hdl.handle.net/11056/13214 https://doi.org/10.1016/j.envres.2014.10.011 |
| _version_ |
1796096584258158592 |
| score |
12.233033 |