Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica
Background: Animal studies have shown that both deficiency and excess manganese (Mn) may result in decreased fetal size and weight, but human studies have reported inconsistent results. Methods: We examined the association of blood and hair Mn concentrations measured at different times during pre...
| Autores Principales: | Mora, Ana María, van Wendel de Joode, Berna, Mergler, Donna, Córdoba, Leonel, Cano, Camilo, Quesada, Rosario, Smith, Donald R, Menezes-Filho, José A., Eskenazi, Brenda |
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| Formato: | Artículo |
| Idioma: | Inglés |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: |
http://hdl.handle.net/11056/13214 https://doi.org/10.1016/j.envres.2014.10.011 |
| Sumario: |
Background: Animal studies have shown that both deficiency and excess manganese (Mn) may result in
decreased fetal size and weight, but human studies have reported inconsistent results.
Methods: We examined the association of blood and hair Mn concentrations measured at different times
during pregnancy with fetal growth among term births and length of gestation in a cohort of 380 mother–infant pairs living near banana plantations aerially sprayed with Mn-containing fungicides in Costa
Rica. We used linear regression and generalized additive models to test for linear and nonlinear associations
Results: Mean (7 SD) blood Mn concentration was 24.476.6 μg/L and geometric mean (geometric SD)
hair Mn concentration was 1.8 (3.2) μg/g. Hair Mn concentrations during the second and third trimesters
of gestation were positively related to infant chest circumference (β for 10-fold increase¼0.62 cm; 95%
CI: 0.16, 1.08; and β¼0.55 cm; 95% CI: 0.16, 1.26, respectively). Similarly, average maternal hair Mn
concentrations during pregnancy were associated with increased chest circumference (β for 10-fold
increase¼1.19 cm; 95% CI: 0.43, 1.95) in infants whose mothers did not have gestational anemia, but not
in infants of mothers who had gestational anemia (β¼0.39 cm; 95% CI: 0.32, 1.10; pINT¼0.14). All these
associations were linear. Blood Mn concentrations did not show consistent linear nor nonlinear relationships with any of the birth outcomes
Conclusions: Mn plays an important role in fetal development, but the extent to which environmental
exposures may cause adverse health effects to the developing fetus is not well understood. Among
women living near banana plantations in Costa Rica, we did not observe linear or nonlinear associations
of Mn concentrations with lowered birth weight or head circumference, as reported in previous studies.
However, we did find positive linear associations between maternal hair Mn concentrations during
pregnancy and infant chest circunference. |
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