Prevalence and geographic distribution of haemophilia in Costa Rica
Haemophilia is the most frequent hereditary haemorrhagic illness and it is due to the deficiency of coagulation factors VIII (haemophilia A, HA) or IX (haemophilia B, HB). The prevalence of this disease varies according to the country, those having better survival rates having also higher prev...
| Autores Principales: | Arroyo, J., Salazar-Sánchez, Lizbeth, Jiménez-Cruz, G., Chaverri, P., Arrieta-Bolaños, E., Morera, Bernal |
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| Formato: | Artículo |
| Idioma: | Inglés |
| Publicado: |
Schattauer (Alemania)
2023
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| Materias: | |
| Acceso en línea: |
http://hdl.handle.net/11056/26750 http://dx.doi.org/10.1055/s-0037-1619065 |
| Sumario: |
Haemophilia is the most frequent hereditary
haemorrhagic illness and it is due to the deficiency
of coagulation factors VIII (haemophilia
A, HA) or IX (haemophilia B, HB). The prevalence
of this disease varies according to the
country, those having better survival rates
having also higher prevalences. Specifically in
Costa Rica, there are around 130 HA and 30
HB families. This study reports the prevalence
and a spatial distribution analysis of both
types of the disease in this country. The prevalence
of haemophilia in this country is 7 cases
per 100 000 men, for HA it is 6 cases per
100 000 and for HB it is 1 case per 100 000
male inhabitants. The prevalence of this disease
is low when compared with other populations.
This low prevalence could be due to
the many patients that have died because of infection with human immunodeficiency virus
during the 1980s. The prevalence of haemophilia
in Costa Rica is almost one half of
that present in developed countries. Nevertheless,
the ratio between HA and HB follows
world tendency: 5 : 1. In this study, nationwide
geographical distribution maps were drawn
in order to visualize the origin of severe cases
and how this influences the pattern of distribution
for both types of haemophilia. By
means of these maps, it was possible to state
that there is no association between the sites
of maximum prevalence of mutated alleles
and ethnicity. With this study, haemophilia
prevalence distribution maps can be used to
improve efforts for the establishment of hemophilia
clinics or specialized health centers
in those areas which hold the highest prevalences
in this country. Also, this knowledge
can be applied to improve treatment skills and
offer the possibility of developing focused
genetic counseling for these populations. |
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