Leukoencephalitis and Vasculitis with Perivascular Demyelination in a Weimaraner Dog
Aseptic and noninfectious diseases of the central nervous system are being recognized with increasing frequency. After multiple episodes of neurologic illness, this 7-year-old Weimaraner dog was eu- thanatized and submitted for postmortem examination. Lesions in the central nervous system were f...
| Autores Principales: | Montgomery, D.L., Pumarola, M., Berrocal Avila, Alexis |
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| Formato: | Artículo |
| Idioma: | Inglés |
| Publicado: |
American College of Veterinary Pathologists
2023
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| Materias: | |
| Acceso en línea: |
http://hdl.handle.net/11056/25719 |
| Sumario: |
Aseptic and noninfectious diseases of the central nervous system are being recognized with
increasing frequency. After multiple episodes of neurologic illness, this 7-year-old Weimaraner dog was eu-
thanatized and submitted for postmortem examination. Lesions in the central nervous system were found mainly
in the white matter of the cerebral cortex and cervical spinal cord and represented acute and more chronic
injury. Necrotizing vasculitis with fibrinoid change and a marked neutrophilic infiltrate dominated the acute
lesions. More chronic changes consisted of perivascular demyelination and accumulation of foamy macrophages
with positive staining for myelin. An immune-complex (Arthus-type) vasculitis is suspected. |
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