Vista Equipo: Mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report

Mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report

This article describes a case of massive mortality among horses which was probably due to intoxication by pyrrolizidine alkaloids from Heliotropium indicum. Over 4 years more than 75% of a population of about 110 horses on a farm in Costa Rica died after showing nervous neurological symptoms. Two cl...

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Autores Principales:	van Weeren, P.R., Rodríguez, L. L., Poveda, L. J., Morales, Juan Alberto, Cedeño Guevara, Humberto, Villalobos, Jorge
Formato:	Artículo
Idioma:	Inglés
Publicado:	Taylor and Francis Group 2022
Materias:	CABALLOS HORSE ALCALOIDES ALKALOIDS NEUROLOGÍA VETERINARIA VETERINARY NEUROLOGY ENVENENAMIENTO POISONING
Acceso en línea:	http://hdl.handle.net/11056/24424 https://doi.org/10.1080/01652176.1999.9694993

id	RepoUNACR24424
recordtype	dspace
spelling	RepoUNACR244242022-12-02T17:43:28Z Mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report van Weeren, P.R. Rodríguez, L. L. Poveda, L. J. Morales, Juan Alberto Cedeño Guevara, Humberto Villalobos, Jorge CABALLOS HORSE ALCALOIDES ALKALOIDS NEUROLOGÍA VETERINARIA VETERINARY NEUROLOGY ENVENENAMIENTO POISONING This article describes a case of massive mortality among horses which was probably due to intoxication by pyrrolizidine alkaloids from Heliotropium indicum. Over 4 years more than 75% of a population of about 110 horses on a farm in Costa Rica died after showing nervous neurological symptoms. Two clinical manifestations were encountered, an acute and a chronic one, both with a fatal outcome. Pathological findings in 2 horses coincided with those reported in the literature for intoxication by pyrrolizidine alkaloids and were not specific for VEE. However Venezuelan equine encephalitis (VEE) was the main differential diagnosis and could not completely be excluded because this disease was endemic in the region and VEE titres were found to be high. Taxonomic and toxicological investigations implicated Heliotropium indicum as the most probable principal cause of the intoxication. Este artículo describe un caso de mortalidad masiva entre caballos que probablemente se debió a la intoxicación por alcaloides pirrolizidínicos de Heliotropium indicum. A lo largo de 4 años, más del 75% de una población de unos 110 caballos en una finca de Costa Rica murió tras mostrar síntomas neurológicos nerviosos. Se encontraron dos manifestaciones clínicas, una aguda y otra crónica, ambas con desenlace fatal. Los hallazgos patológicos en 2 caballos coincidieron con los reportados en la literatura para la intoxicación por alcaloides de pirrolizidina y no fueron específicos para la EEV. Sin embargo, la encefalitis equina venezolana (EVE) fue el principal diagnóstico diferencial y no pudo excluirse por completo, ya que esta enfermedad era endémica en la región y los títulos de EVE resultaron ser elevados. Las investigaciones taxonómicas y toxicológicas implicaron al Heliotropium indicum como la causa principal más probable de la intoxicación. Universidad Nacional, Costa Rica Escuela de Medicina Veterinaria 2022-12-02T17:37:54Z 2022-12-02T17:37:54Z 2011-11-01 http://purl.org/coar/resource_type/c_6501 http://hdl.handle.net/11056/24424 https://doi.org/10.1080/01652176.1999.9694993 eng Acceso abierto http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Taylor and Francis Group Veterinary Quarterly, 21(2): 59-62, 2011
institution	Universidad Nacional de Costa Rica
collection	Repositorio UNA-Costa Rica
language	Inglés
topic	CABALLOS HORSE ALCALOIDES ALKALOIDS NEUROLOGÍA VETERINARIA VETERINARY NEUROLOGY ENVENENAMIENTO POISONING
spellingShingle	CABALLOS HORSE ALCALOIDES ALKALOIDS NEUROLOGÍA VETERINARIA VETERINARY NEUROLOGY ENVENENAMIENTO POISONING van Weeren, P.R. Rodríguez, L. L. Poveda, L. J. Morales, Juan Alberto Cedeño Guevara, Humberto Villalobos, Jorge Mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report
description	This article describes a case of massive mortality among horses which was probably due to intoxication by pyrrolizidine alkaloids from Heliotropium indicum. Over 4 years more than 75% of a population of about 110 horses on a farm in Costa Rica died after showing nervous neurological symptoms. Two clinical manifestations were encountered, an acute and a chronic one, both with a fatal outcome. Pathological findings in 2 horses coincided with those reported in the literature for intoxication by pyrrolizidine alkaloids and were not specific for VEE. However Venezuelan equine encephalitis (VEE) was the main differential diagnosis and could not completely be excluded because this disease was endemic in the region and VEE titres were found to be high. Taxonomic and toxicological investigations implicated Heliotropium indicum as the most probable principal cause of the intoxication.
format	Artículo
author	van Weeren, P.R. Rodríguez, L. L. Poveda, L. J. Morales, Juan Alberto Cedeño Guevara, Humberto Villalobos, Jorge
author_sort	van Weeren, P.R.
title	Mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report
title_short	Mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report
title_full	Mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report
title_fullStr	Mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report
title_full_unstemmed	Mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report
title_sort	mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report
publisher	Taylor and Francis Group
publishDate	2022
url	http://hdl.handle.net/11056/24424 https://doi.org/10.1080/01652176.1999.9694993
_version_	1803793733992316928
score	12.19327

Mortality supposedly due to intoxication by pyrrolizidine alkaloids from heliotropium indicum in a horse population in costa rica: a case report

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