In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
The in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2- nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were tested against cultures of the parasite Trypanosoma cruzi. Cytotoxici...
Autores Principales: | Herrera, Cristina, Vallejos, Gabriel, Loaiza, Randall, Zeledón, Rodrigo, Urbina, Andrea, Sepúlveda-Boza, Silvia |
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Formato: | Artículo |
Idioma: | Inglés |
Publicado: |
Memórias do Instituto Oswaldo Cruz
2022
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Materias: | |
Acceso en línea: |
http://hdl.handle.net/11056/23635 |
Sumario: |
The in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2-
nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were
tested against cultures of the parasite Trypanosoma cruzi. Cytotoxicity studies were performed using Vero cells. The
blood trypomastigotes, amastigotes and epimastigotes showed differential degrees of sensitivity towards the four
tested compounds; the highest activity against the epimastigotes and blood tripomastigotes was exhibited by N1,
followed by N3, N4 and finally N2. In contrast, whereas the compounds N1, N3 and N4 exerted similar magnitudes
of activity against amastigotes, N2 was found to be a much less potent compound. According to our results, the com pound N1 had the highest level of activity (IC50: 0.6 µM) against epimastigotes. |
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