Antimicrobial activity of the heliangolide chromolaenide and related sesquiterpene lactones
Some sesquiterpene lactones are known to exhibit antimicrobial activity [1, 2]. More recently, it has been noted that the pseudoguainolide carpesiolin inhibits the growth of Xanthomonas oryzae [3]. Here, we report on the antimicrobial activity of the heliangolide chromolaenide 1, isolated from...
| Autores Principales: | Ciccio, José, Echandi, Guillermo, Calzada, José |
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| Formato: | Artículo |
| Idioma: | Inglés |
| Publicado: |
Pergamon Press
2022
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| Materias: | |
| Acceso en línea: |
http://hdl.handle.net/11056/22872 https://doi.org/10.1016/0031-9422(80)85151-x |
| Sumario: |
Some sesquiterpene lactones are known to exhibit
antimicrobial activity [1, 2]. More recently, it has been
noted that the pseudoguainolide carpesiolin inhibits
the growth of Xanthomonas oryzae [3]. Here, we
report on the antimicrobial activity of the heliangolide
chromolaenide 1, isolated from Chromolaena glaberrima (DC.) King et Robinson [4] and its derivatives,
against Staphylococcus aureus.
The results are summarized in Table 1. It is apparent that there is a clear dependence between antimicrobial activity and the presence of the t~-methylene-3,-
iactone group. As already established [5-8], the
growth inhibition of microorganisms is caused by the
alkylation of their nucleophilic centers (R-SH) with
the unsaturated lactone moiety. This observation is
congruent with our results, because the only inactive
compound was 3, which is the one with no unsaturated
lactone. |
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