The effect of solution environment and the electrostatic factor on the crystallisation of desmotropes of irbesartan
The experimental conditions necessary for stabilising irbesartan (IBS) tautomers in solution and selectively obtaining the desmotropic crystal forms are presented herein. 1H and 2H tautomers were stabilized in specific solution conditions and the 2H-tetrazole/imidazole interaction was confirmed by...
| Autores Principales: | Araya, Andrea, Urgelles, Mariola, Vásquez Castro, Felipe, Vargas-Huertas, Felipe, Jose-Roberto, Vega-Baudrit, Guillen-Girón, Teodolito, Navarro-Hoyos, Mirtha, Cuffini, Silvia Lucia |
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| Formato: | Artículo |
| Idioma: | Inglés |
| Publicado: |
Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: |
http://hdl.handle.net/11056/22338 |
| Sumario: |
The experimental conditions necessary for stabilising irbesartan (IBS) tautomers in solution and selectively
obtaining the desmotropic crystal forms are presented herein. 1H and 2H tautomers were stabilized in
specific solution conditions and the 2H-tetrazole/imidazole interaction was confirmed by solution-state
NMR. The results showed that highly polar and polarisable solvents (higher values of the electrostatic
factor (EF)) lead to the crystallisation of IBS form B. Furthermore, the variations of pH in methanol, in
turn, determined the crystallisation of desmotropes A and/or B |
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