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What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?

Over the years of evolution, thousands of di erent animal species have evolved. All these species require an immune system to defend themselves against invading pathogens. Nevertheless, the immune systems of di erent species are obviously counteracting against the same pathogen with di erent e ci...

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Autores Principales: Dolz, Gaby, Fingerhut, Leonie, de Buhr, Nicole
Formato: Artículo
Idioma: Inglés
Publicado: University of Veterinary Medicine Hannover, Hannover, Germany 2020
Materias:
INMUNOLOGÍA
NEUTROPHILS
SPECIES
GRANULOCYTES
ANIMALES
SERES HUMANOS
Acceso en línea: http://hdl.handle.net/11056/17731
id RepoUNACR17731
recordtype dspace
spelling RepoUNACR177312020-07-25T09:01:04Z What Is the Evolutionary Fingerprint in Neutrophil Granulocytes? Dolz, Gaby Fingerhut, Leonie de Buhr, Nicole INMUNOLOGÍA NEUTROPHILS SPECIES GRANULOCYTES ANIMALES SERES HUMANOS Over the years of evolution, thousands of di erent animal species have evolved. All these species require an immune system to defend themselves against invading pathogens. Nevertheless, the immune systems of di erent species are obviously counteracting against the same pathogen with di erent e ciency. Therefore, the question arises if the process that was leading to the clades of vertebrates in the animal kingdom—namely mammals, birds, amphibians, reptiles, and fish—was also leading to di erent functions of immune cells. One cell type of the innate immune system that is transmigrating as first line of defense in infected tissue and counteracts against pathogens is the neutrophil granulocyte. During the host–pathogen interaction they can undergo phagocytosis, apoptosis, degranulation, and form neutrophil extracellular traps (NETs). In this review, wesummarize a wide spectrum of information about neutrophils in humans and animals, with a focus on vertebrates. Special attention is kept on the development, morphology, composition, and functions of these cells, but also on dysfunctions and options for cell culture or storage. A lo largo de los años de evolución, miles de especies animales existentes han evolucionado. Todas estas especies requieren un sistema inmunológico para defenderse de los patógenos invasores. Sin embargo, los sistemas inmunes de las especies existentes están obviamente contrarrestando el mismo patógeno con la ciencia moderna. Por lo tanto, se plantea la cuestión de si el proceso que estaba conduciendo a los clados de vertebrados en el reino animal -es decir, mamíferos, aves, anfibios, reptiles y peces- también estaba conduciendo a funciones deficientes de las células inmunitarias. Un tipo de célula del sistema inmunológico innato que se transmigra como primera línea de defensa en el tejido infectado y contrarresta los patógenos es el granulocito de neutrófilo. Durante la interacción huésped-patógeno pueden sufrir fagocitosis, apoptosis, degranulación y formar trampas extracelulares de neutrófilos (NETs). En esta revisión, resumimos un amplio espectro de información sobre los neutrófilos en humanos y animales, centrándonos en los vertebrados. Se presta especial atención al desarrollo, la morfología, la composición y las funciones de estas células, pero también a las disfunciones y las opciones de cultivo o almacenamiento celular. Escuela de Medicina Veterinaria 2020-07-24T21:28:27Z 2020-07-24T21:28:27Z 2020-06-25 http://purl.org/coar/resource_type/c_6501 http://hdl.handle.net/11056/17731 doi:10.3390/ijms21124523 eng Acceso abierto http://creativecommons.org/publicdomain/zero/1.0/ application/pdf University of Veterinary Medicine Hannover, Hannover, Germany Int. J. Mol. Sci. vol. 21, 4523 (2020)
institution Universidad Nacional de Costa Rica
collection Repositorio UNA-Costa Rica
language Inglés
topic INMUNOLOGÍA
NEUTROPHILS
SPECIES
GRANULOCYTES
ANIMALES
SERES HUMANOS
spellingShingle INMUNOLOGÍA
NEUTROPHILS
SPECIES
GRANULOCYTES
ANIMALES
SERES HUMANOS
Dolz, Gaby
Fingerhut, Leonie
de Buhr, Nicole
What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?
description Over the years of evolution, thousands of di erent animal species have evolved. All these species require an immune system to defend themselves against invading pathogens. Nevertheless, the immune systems of di erent species are obviously counteracting against the same pathogen with di erent e ciency. Therefore, the question arises if the process that was leading to the clades of vertebrates in the animal kingdom—namely mammals, birds, amphibians, reptiles, and fish—was also leading to di erent functions of immune cells. One cell type of the innate immune system that is transmigrating as first line of defense in infected tissue and counteracts against pathogens is the neutrophil granulocyte. During the host–pathogen interaction they can undergo phagocytosis, apoptosis, degranulation, and form neutrophil extracellular traps (NETs). In this review, wesummarize a wide spectrum of information about neutrophils in humans and animals, with a focus on vertebrates. Special attention is kept on the development, morphology, composition, and functions of these cells, but also on dysfunctions and options for cell culture or storage.
format Artículo
author Dolz, Gaby
Fingerhut, Leonie
de Buhr, Nicole
author_sort Dolz, Gaby
title What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?
title_short What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?
title_full What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?
title_fullStr What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?
title_full_unstemmed What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?
title_sort what is the evolutionary fingerprint in neutrophil granulocytes?
publisher University of Veterinary Medicine Hannover, Hannover, Germany
publishDate 2020
url http://hdl.handle.net/11056/17731
_version_ 1796096914173722624
score 12.231669

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