Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates
Hollow poly(Lactic Acid) (PLA) microcapsules were fabricated using the bubble template method. In this method, microbubbles nucleated inside droplets of a dichloromethane solution of PLA which were located in a continuous phase of poly(vinyl alcohol). PLA-covered microbubbles formed when PLA ads...
| Autores Principales: | Molino, Jay, Jojlova, Svetlana, Hirofumi Daiguji and, Takemura, Fumio |
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| Formato: | Artículo |
| Idioma: | Inglés |
| Publicado: |
.American Journal of Applied Sciences
2021
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| Acceso en línea: |
http://repositorio2.udelas.ac.pa/handle/123456789/362 |
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RepoUDELAS362 |
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RepoUDELAS3622023-09-13T17:35:18Z Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates Molino, Jay Jojlova, Svetlana Hirofumi Daiguji and Takemura, Fumio Biodegradable Microcapsules Drug Delivery Mass Production of Hollow Capsules Microencapsulation Ultrasound Enhanced Fabrication Ultrasound Contrast Agents Hollow poly(Lactic Acid) (PLA) microcapsules were fabricated using the bubble template method. In this method, microbubbles nucleated inside droplets of a dichloromethane solution of PLA which were located in a continuous phase of poly(vinyl alcohol). PLA-covered microbubbles formed when PLA adsorbed to the bubble surface by physisorption. Then, the coated microbubbles were spontaneously released from the droplet´s interior into the continuous phase. To increase the production yield of hollow microcapsules in this method, ultrasound was applied to enhance bubble nucleation inside the droplets. Thus to attain uniform hollow PLA microcapsules, the optimum PLA concentration with ultrasound was 30 g L −1 , which is higher than that without ultrasound (2 g L−1 ). At the optimum concentration, the average radius was 0.54 µm, with a polydispersity index of 21.2%. It was found that the equilibrium size of the microbubble template radius was the same with and without ultrasound. The production yield had a tenfold increase when ultrasound was employed. 2021-05-18T19:55:39Z 2021-05-18T19:55:39Z 2019-01-16 info:eu-repo/semantics/article info:eu-repo/semantics/updatedVersion DOI: 10.3844/ajassp.2019.213.224 http://repositorio2.udelas.ac.pa/handle/123456789/362 eng https://creativecommons.org/licenses/by-nc-sa/4.0/ https://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-sa/2.0/uk/ https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf 213-224 páginas application/pdf .American Journal of Applied Sciences |
| institution |
Universidad Especializada de las Américas |
| collection |
Repositorio UDELAS |
| language |
Inglés |
| topic |
Biodegradable Microcapsules Drug Delivery Mass Production of Hollow Capsules Microencapsulation Ultrasound Enhanced Fabrication Ultrasound Contrast Agents |
| spellingShingle |
Biodegradable Microcapsules Drug Delivery Mass Production of Hollow Capsules Microencapsulation Ultrasound Enhanced Fabrication Ultrasound Contrast Agents Molino, Jay Jojlova, Svetlana Hirofumi Daiguji and Takemura, Fumio Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates |
| description |
Hollow poly(Lactic Acid) (PLA) microcapsules were fabricated
using the bubble template method. In this method, microbubbles nucleated
inside droplets of a dichloromethane solution of PLA which were located in
a continuous phase of poly(vinyl alcohol). PLA-covered microbubbles
formed when PLA adsorbed to the bubble surface by physisorption. Then,
the coated microbubbles were spontaneously released from the droplet´s
interior into the continuous phase. To increase the production yield of
hollow microcapsules in this method, ultrasound was applied to enhance
bubble nucleation inside the droplets. Thus to attain uniform hollow PLA
microcapsules, the optimum PLA concentration with ultrasound was 30 g
L
−1
, which is higher than that without ultrasound (2 g L−1
). At the optimum
concentration, the average radius was 0.54 µm, with a polydispersity index
of 21.2%. It was found that the equilibrium size of the microbubble
template radius was the same with and without ultrasound. The production
yield had a tenfold increase when ultrasound was employed. |
| format |
Artículo |
| author |
Molino, Jay Jojlova, Svetlana Hirofumi Daiguji and Takemura, Fumio |
| author_sort |
Molino, Jay |
| title |
Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates |
| title_short |
Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates |
| title_full |
Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates |
| title_fullStr |
Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates |
| title_full_unstemmed |
Mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates |
| title_sort |
mass production of uniformly sized air-filled poly-lactic acid microcapsules made from microbubble templates |
| publisher |
.American Journal of Applied Sciences |
| publishDate |
2021 |
| url |
http://repositorio2.udelas.ac.pa/handle/123456789/362 |
| _version_ |
1796503348342423552 |
| score |
12.043409 |