Bioactivity profiling of plant biodiversity of Panama by high throughput screening
We report relative bioactivities of extracts prepared from a large collection of plants from three national parks in Panama. Over 181 plants were collected, taxonomically identified and their detannified dichloromethane (DCM)-methanolic extracts were used for profiling selected bioactivities. Assay...
| Autores Principales: | Roy, Anuradha, McDonald, Peter, Timmermann, Barbara N., Gupta, Mahabir, Chaguturu, Rathnam |
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| Formato: | Artículo |
| Idioma: | Español |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: |
http://up-rid.up.ac.pa/6887/ http://up-rid.up.ac.pa/6887/1/anuradha_roy.pdf |
| Sumario: |
We report relative bioactivities of extracts prepared from a large collection of plants from three national parks in Panama. Over 181 plants were collected,
taxonomically identified and their detannified dichloromethane (DCM)-methanolic extracts were used for profiling selected bioactivities. Assays were
performed to evaluate the antioxidant activity of the extracts for Antioxidant Response Element (ARE) induction, total non-enzymatic antioxidant potential,
anti-inflammatory and anticancer properties. The high throughput analysis of 280 extracts resulted in identification of 57.5% of the extracts that could induce
ARE at one or more concentrations tested, 93.5% that harbored total antioxidant capacity, and 2.1% of the extracts that showed lung cancer cell line-specific
cytotoxicity. Data from our profiling experiments indicate that a large number of extracts could be a source for further isolation and chemical identification of
compounds that could serve as leads for discovery of antioxidant, anticancer and anti-inflammatory agents to prevent or treat complex diseases like cancer and
neurodegenerative disorders. |
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