Vista Equipo: Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA).

Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA).

Background: Mancozeb and its main metabolite ethylene thiourea (ETU) may alter thyroid function; thyroid hormones are essential for fetal brain development. In Costa Rica, mancozeb is aerially sprayed at large-scale banana plantations on a weekly basis. Objectives: Our goals were to evaluate urin...

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Autores Principales:	van Wendel de Joode, Berna, Mora, Ana María, Córdoba, Leonel, Cano, Camilo, Quesada, Rosario, Faniband, Moosa, Wesseling, Catharina, Ruepert, Clemens, Oberg, Mathias, Eskenazi, Brenda, Mergler, Donna, Lindh, Christian
Formato:	Artículo
Idioma:	Inglés
Publicado:	Research: Children´s health 2016
Materias:	SUSTANCIAS TÓXICAS RIESGOS PARA LA SALUD SALUD PÚBLICA PROGRAMA INFANTES Y SALUD AMBIENTAL ISA TOXIC SUBSTANCES PUBLIC HEALTH HEALTH RISKS
Acceso en línea:	http://hdl.handle.net/11056/13215

id	RepoUNACR13215
recordtype	dspace
spelling	RepoUNACR132152021-11-05T15:26:10Z Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA). van Wendel de Joode, Berna Mora, Ana María Córdoba, Leonel Cano, Camilo Quesada, Rosario Faniband, Moosa Wesseling, Catharina Ruepert, Clemens Oberg, Mathias Eskenazi, Brenda Mergler, Donna Lindh, Christian SUSTANCIAS TÓXICAS RIESGOS PARA LA SALUD SALUD PÚBLICA PROGRAMA INFANTES Y SALUD AMBIENTAL ISA TOXIC SUBSTANCES PUBLIC HEALTH HEALTH RISKS Background: Mancozeb and its main metabolite ethylene thiourea (ETU) may alter thyroid function; thyroid hormones are essential for fetal brain development. In Costa Rica, mancozeb is aerially sprayed at large-scale banana plantations on a weekly basis. Objectives: Our goals were to evaluate urinary ETU concentrations in pregnant women living near large-scale banana plantations, compare their estimated daily intake (EDI) with established reference doses (RfDs), and identify factors that predict their urinary ETU concentrations. Methods: We enrolled 451 pregnant women from Matina County, Costa Rica, which has large-scale banana production. We visited 445 women up to three times during pregnancy to obtain urine samples (n = 872) and information on factors that possibly influence exposure. We determined urinary ETU concentrations using liquid chromatography mass spectrometry. Results: Pregnant women’s median urinary ETU concentrations were more than five times higher than those reported for other general populations. Seventy-two percent of the women had EDIs above the RfD. Women who lived closest (1st quartile, < 48 m) to banana plantations on average had a 45% (95% CI: 23, 72%) higher urinary ETU compared with women who lived farthest away (4th quartile, ≥ 565 m). Compared with the other women, ETU was also higher in women who washed agricultural work clothes on the day before sampling (11%; 95% CI: 4.9, 17%), women who worked in agriculture during pregnancy (19%; 95% CI: 9.3, 29%), and immigrant women (6.2%; 95% CI: 1.0, 13%). Conclusions: The pregnant women’s urinary ETU concentrations are of concern, and the principal source of exposure is likely to be aerial spraying of mancozeb. The factors predicting ETU provide insight into possibilities for exposure reduction. Antecedentes: El mancozeb y su principal metabolito, la tiourea de etileno (ETU), pueden alterar la tiroides Las hormonas tiroideas son esenciales para el desarrollo del cerebro del feto. En Costa Rica, el mancozeb es rociado aéreo en las grandes plantaciones de plátanos semanalmente. Objetivos: Nuestros objetivos eran evaluar las concentraciones de ETU en la orina de las mujeres embarazadas que viven cerca de plantaciones de banano en gran escala, comparen su ingesta diaria estimada (IDE) con la establecida dosis de referencia (RfD), e identificar los factores que predicen sus concentraciones de ETU en orina. Métodos: Inscribimos a 451 mujeres embarazadas del condado de Matina, Costa Rica, que ha producción de bananas a gran escala. Visitamos a 445 mujeres hasta tres veces durante el embarazo para obtener muestras de orina (n = 872) e información sobre los factores que posiblemente influyan en la exposición. Nosotros determinó las concentraciones urinarias de ETU usando la cromatografía líquida de espectrometría de masas. Resultados: Las concentraciones medias de ETU urinaria de las mujeres embarazadas fueron más de cinco veces más altas que las comunicadas para otras poblaciones generales. El setenta y dos por ciento de las mujeres tenían EDIs por encima del RfD. Las mujeres que vivían más cerca (1er cuartil, < 48 m) de las plantaciones de plátanos en promedio tenía un 45% (95% CI: 23, 72%) más de ETU urinaria en comparación con las mujeres que vivían más lejos. (4º cuartil, ≥ 565 m). En comparación con las otras mujeres, la ETU fue también más alta en las mujeres que lavó la ropa de trabajo agrícola el día antes de la toma de muestras (11%; 95% CI: 4,9, 17%), las mujeres que trabajaron en la agricultura durante el embarazo (19%; 95% CI: 9,3, 29%), y las mujeres inmigrantes (6,2%; 95% CI: 1,0, 13%). Conclusiones: Las concentraciones de ETU urinaria de las mujeres embarazadas son preocupantes, y el La principal fuente de exposición es probablemente la pulverización aérea de mancozeb. Los factores que predicen la ETU proporcionan una visión de las posibilidades de reducción de la exposición. Universidad Nacional, Costa Rica University of California at Berkeley, Berkeley, California, USA Lund University, Lund, Sweden Karolinska Institutet, Stockholm, Sweden Université du Québec a Montréal, Montréal, Québec, Canada Instituto Regional de Estudios en Sustancias Tóxicas, Universidad Nacional, Costa Rica Center for Environmental Research and Children’s Health (CERCH), School of Public Health, University of California at Berkeley Division of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University Institute of Environmental Medicine, Karolinska Institutet, Stockholm Centre de recherche interdisciplinaire sur la biologie la santé et l’environnement (CINBIOSE), Université du Québec a Montréal 2016-10-13T21:18:02Z 2016-10-13T21:18:02Z 2014-12 http://purl.org/coar/resource_type/c_6501 http://hdl.handle.net/11056/13215 en application/pdf Research: Children´s health Environmental Health Perspectives vol.122 no.12 1321-1327 2014
institution	Universidad Nacional de Costa Rica
collection	Repositorio UNA-Costa Rica
language	Inglés
topic	SUSTANCIAS TÓXICAS RIESGOS PARA LA SALUD SALUD PÚBLICA PROGRAMA INFANTES Y SALUD AMBIENTAL ISA TOXIC SUBSTANCES PUBLIC HEALTH HEALTH RISKS
spellingShingle	SUSTANCIAS TÓXICAS RIESGOS PARA LA SALUD SALUD PÚBLICA PROGRAMA INFANTES Y SALUD AMBIENTAL ISA TOXIC SUBSTANCES PUBLIC HEALTH HEALTH RISKS van Wendel de Joode, Berna Mora, Ana María Córdoba, Leonel Cano, Camilo Quesada, Rosario Faniband, Moosa Wesseling, Catharina Ruepert, Clemens Oberg, Mathias Eskenazi, Brenda Mergler, Donna Lindh, Christian Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA).
description	Background: Mancozeb and its main metabolite ethylene thiourea (ETU) may alter thyroid function; thyroid hormones are essential for fetal brain development. In Costa Rica, mancozeb is aerially sprayed at large-scale banana plantations on a weekly basis. Objectives: Our goals were to evaluate urinary ETU concentrations in pregnant women living near large-scale banana plantations, compare their estimated daily intake (EDI) with established reference doses (RfDs), and identify factors that predict their urinary ETU concentrations. Methods: We enrolled 451 pregnant women from Matina County, Costa Rica, which has large-scale banana production. We visited 445 women up to three times during pregnancy to obtain urine samples (n = 872) and information on factors that possibly influence exposure. We determined urinary ETU concentrations using liquid chromatography mass spectrometry. Results: Pregnant women’s median urinary ETU concentrations were more than five times higher than those reported for other general populations. Seventy-two percent of the women had EDIs above the RfD. Women who lived closest (1st quartile, < 48 m) to banana plantations on average had a 45% (95% CI: 23, 72%) higher urinary ETU compared with women who lived farthest away (4th quartile, ≥ 565 m). Compared with the other women, ETU was also higher in women who washed agricultural work clothes on the day before sampling (11%; 95% CI: 4.9, 17%), women who worked in agriculture during pregnancy (19%; 95% CI: 9.3, 29%), and immigrant women (6.2%; 95% CI: 1.0, 13%). Conclusions: The pregnant women’s urinary ETU concentrations are of concern, and the principal source of exposure is likely to be aerial spraying of mancozeb. The factors predicting ETU provide insight into possibilities for exposure reduction.
format	Artículo
author	van Wendel de Joode, Berna Mora, Ana María Córdoba, Leonel Cano, Camilo Quesada, Rosario Faniband, Moosa Wesseling, Catharina Ruepert, Clemens Oberg, Mathias Eskenazi, Brenda Mergler, Donna Lindh, Christian
author_sort	van Wendel de Joode, Berna
title	Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA).
title_short	Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA).
title_full	Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA).
title_fullStr	Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA).
title_full_unstemmed	Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA).
title_sort	aerial application of mancozeb and urinary ethylene thiourea (etu) concentrations among pregnant women in costa rica: the infants' environmental health study (isa).
publisher	Research: Children´s health
publishDate	2016
url	http://hdl.handle.net/11056/13215
_version_	1796095560822816768
score	12.043282

Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA).

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