Skin grafts and substitutes developed by Tissue Engineering
Tissue Engineering strategies for tissue and organ regeneration have allowed the fabrication and commercialization of diverse skin substitutes, which have been applied in different parts of the world on human patients over the course of the last 30 years. These grafts have been developed using biode...
| Autores Principales: | Chaves-Rodríguez, María Inés, Calvo-Castro, Laura A., Alvarado-Meza, Ricardo, Madrigal-Monge, Olman, Ulloa-Fernández, Andrea, Centeno-Cerdas, Carolina |
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| Formato: | Artículo |
| Idioma: | Español |
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Editorial Tecnológica de Costa Rica
2015
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https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/2219 https://hdl.handle.net/2238/8993 |
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RepoTEC8993 |
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RepoTEC89932017-09-19T20:38:10Z Skin grafts and substitutes developed by Tissue Engineering Sustitutos e injertos de piel desarrollados por ingeniería de tejidos Chaves-Rodríguez, María Inés Calvo-Castro, Laura A. Alvarado-Meza, Ricardo Madrigal-Monge, Olman Ulloa-Fernández, Andrea Centeno-Cerdas, Carolina Skin; cell culture; Tissue Engineering; transplant; graft; epithelial equivalents. Piel; cultivo celular; ingeniería de tejidos; trasplante; injerto; equivalentes epiteliales. Tissue Engineering strategies for tissue and organ regeneration have allowed the fabrication and commercialization of diverse skin substitutes, which have been applied in different parts of the world on human patients over the course of the last 30 years. These grafts have been developed using biodegradable materials (of natural or synthetic origin) as scaffolds for the adhesion and proliferation of cells that may be of different origins (autologous, allogenic and xenogenic). The main clinical advantage of these materials is to provide an effective re-epitelization of large wounds, which is particularly relevant when there is little tissue available for autografts. Also, skin equivalents provide coverage for skin lesions, avoiding dehydration and microbial infections. Despite these advantages, there are still many challenges to solve including the immediate functionality and long term permanency of the grafts and the exact reproduction of the normal tissue structure and physiology. In Costa Rica, the only laboratory dedicated to in vitro skin cell culture for reconstructing epithelial equivalents with therapeutic applications is located at the Biotechnology Research Center at the Costa Rica Institute of Technology. La reconstrucción de tejidos y órganos mediante ingeniería de tejidos ha permitido la elaboración y comercialización de diversos sustitutos o equivalentes epiteliales, que han sido utilizados desde hace más de 30 años a escala internacional para el tratamiento de lesiones en pacientes humanos. Estos injertos o implantes se confeccionan con materiales biodegradables (naturales o polímeros sintéticos) que sirven como matrices para la adhesión y proliferación celular y pueden contener células de diversos orígenes (autólogas, alogénicas o xenogénicas). Su principal ventaja clínica consiste en proporcionar una reepitelización efectiva en lesiones de gran extensión, lo que es particularmente relevante cuando hay poco tejido disponible para hacer autoinjertos. Además, ofrecen una cobertura al lecho de la lesión, evitando la deshidratación y las infecciones microbianas. Sin embargo, aún existen numerosos retos para asegurar la funcionalidad inmediata y la permanencia a largo plazo de los implantes, así como la reproducción exacta de la estructura y fisiología normal del tejido. En Costa Rica, el Centro de Investigación en Biotecnología del Instituto Tecnológico de Costa Rica cuenta con el único laboratorio en el país dedicado al cultivo in vitro de células de piel para la reconstrucción de equivalentes epiteliales con fines terapéuticos. 2015-05-01 2017-09-19T20:38:10Z 2017-09-19T20:38:10Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artículo revisado por pares https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/2219 10.18845/tm.v28i5.2219 https://hdl.handle.net/2238/8993 spa https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/2219/2014 Copyright (c) 2015 Tecnología en Marcha application/pdf Editorial Tecnológica de Costa Rica Revista Tecnología en Marcha; Revista Tecnología en Marcha. Ingeniería de Tejidos. Mayo 2015; pág. 46-57 2215-3241 0379-3982 |
| institution |
Tecnológico de Costa Rica |
| collection |
Repositorio TEC |
| language |
Español |
| topic |
Skin; cell culture; Tissue Engineering; transplant; graft; epithelial equivalents. Piel; cultivo celular; ingeniería de tejidos; trasplante; injerto; equivalentes epiteliales. |
| spellingShingle |
Skin; cell culture; Tissue Engineering; transplant; graft; epithelial equivalents. Piel; cultivo celular; ingeniería de tejidos; trasplante; injerto; equivalentes epiteliales. Chaves-Rodríguez, María Inés Calvo-Castro, Laura A. Alvarado-Meza, Ricardo Madrigal-Monge, Olman Ulloa-Fernández, Andrea Centeno-Cerdas, Carolina Skin grafts and substitutes developed by Tissue Engineering |
| description |
Tissue Engineering strategies for tissue and organ regeneration have allowed the fabrication and commercialization of diverse skin substitutes, which have been applied in different parts of the world on human patients over the course of the last 30 years. These grafts have been developed using biodegradable materials (of natural or synthetic origin) as scaffolds for the adhesion and proliferation of cells that may be of different origins (autologous, allogenic and xenogenic). The main clinical advantage of these materials is to provide an effective re-epitelization of large wounds, which is particularly relevant when there is little tissue available for autografts. Also, skin equivalents provide coverage for skin lesions, avoiding dehydration and microbial infections. Despite these advantages, there are still many challenges to solve including the immediate functionality and long term permanency of the grafts and the exact reproduction of the normal tissue structure and physiology. In Costa Rica, the only laboratory dedicated to in vitro skin cell culture for reconstructing epithelial equivalents with therapeutic applications is located at the Biotechnology Research Center at the Costa Rica Institute of Technology. |
| format |
Artículo |
| author |
Chaves-Rodríguez, María Inés Calvo-Castro, Laura A. Alvarado-Meza, Ricardo Madrigal-Monge, Olman Ulloa-Fernández, Andrea Centeno-Cerdas, Carolina |
| author_sort |
Chaves-Rodríguez, María Inés |
| title |
Skin grafts and substitutes developed by Tissue Engineering |
| title_short |
Skin grafts and substitutes developed by Tissue Engineering |
| title_full |
Skin grafts and substitutes developed by Tissue Engineering |
| title_fullStr |
Skin grafts and substitutes developed by Tissue Engineering |
| title_full_unstemmed |
Skin grafts and substitutes developed by Tissue Engineering |
| title_sort |
skin grafts and substitutes developed by tissue engineering |
| publisher |
Editorial Tecnológica de Costa Rica |
| publishDate |
2015 |
| url |
https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/2219 https://hdl.handle.net/2238/8993 |
| _version_ |
1796139003710275584 |
| score |
12.043273 |