Determinación de parámetros fitoquímicos, toxicológicos y farmacológicos de tres plantas usadas en la medicina tradicional panameña por sus efectos a nivel del sistema reproductivo femenino.

Phytochemical and toxicological parameters of the plants Centaurim erythraea (Canchalagua), Calophyllum brasiliense (Palo Maria) and Siparuna panamensis (Pasmo Cafe), traditionally used in Panama, as regulators of the menstrual cycle. abortifbcient and in other health conditions were evaluated. S...

Full description

Main Author: Pitti Rodríguez, Meybis Ivett
Other Authors: Gómez Martínez, Lisbeth
Format: Tesis
Language: Español
Published: Universidad Autónoma de Chiriquí 2023
Subjects:
Online Access: http://jadimike.unachi.ac.pa/handle/123456789/934
Summary: Phytochemical and toxicological parameters of the plants Centaurim erythraea (Canchalagua), Calophyllum brasiliense (Palo Maria) and Siparuna panamensis (Pasmo Cafe), traditionally used in Panama, as regulators of the menstrual cycle. abortifbcient and in other health conditions were evaluated. Standardized phytochemical of the hydroalcoholic extract of C. erythraea showed a significant presence of flavonoids, tannins and glycosides. The leaves of Siparuna guianensis showed a higher presence of saponins, alkaloids and glycosides and the hydroalcoholic extract of C. brasiliense bark showed a high proportion of alkaloids, sterols. triterpenes, tannins, saponins and coumarins. The acute toxicity of these plants was evaluated by means of he Anemia salina test(Meyer, 1982). The Legal Concentration 50 (LC50), obtained by Probit Analysis acer 24 hours of exposure of the nauplius to diflbrent concentrations of he hydroalcoholic extracts was, for C. erythmea of 114.670 po/ ml. for Calophyllum brasiliense 599.06 po/ ml, and for Sparuna guianensis, 1,176.87 ug/ ml. These values indicate that C. eryfhraea does not present considerable toxicity like Sparuna guianensis, however, C. brasiliense did show a moderate potential for toxicity These results were confirmed in female Wistar rats, in which C. brasiliense at an intraperitoneal dose of 50 mg / kg, it produced bristly hair, nose and eye bleeding. and general weakness, and at a dose of 100 mg/ kg, 90% of the animals died. These results could be related to the high presence of tannins, saponins and coumarins observed in this plant. Keywords: Centaurium erythraea Calophyllum brasiliense Siparuns guianentis Phytochemicals creening, Artemia salina.