Vista Equipo: Recombinant protein production from transgenic animals: Systems and applications

Recombinant protein production from transgenic animals: Systems and applications

The use of transgenic animals for the production of recombinant proteins for therapeutic purposes has been an alternative used for the production of drugs. The ability to make complex post-translational modifications in an efficient manner is an advantage that this type of technology has over the us...

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Autores Principales:	Alvarado-Madrigal, María Fernanda, Chavarría-Quirós, Tannia, Leiva-Montero, Brayan, Mora-Román, Juan José
Formato:	Artículo
Idioma:	Español
Publicado:	Editorial Tecnológica de Costa Rica (entidad editora) 2019
Materias:	Biotechnology Genetic engineering transgenic animals recombinant proteins Biotecnología Ingeniería Genética animales transgénicos proteínas recombinantes
Acceso en línea:	https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/4798 https://hdl.handle.net/2238/12026

id	RepoTEC12026
recordtype	dspace
spelling	RepoTEC120262020-09-25T23:12:44Z Recombinant protein production from transgenic animals: Systems and applications Producción de proteínas recombinantes a partir de animales transgénicos: Sistemas y aplicaciones Alvarado-Madrigal, María Fernanda Chavarría-Quirós, Tannia Leiva-Montero, Brayan Mora-Román, Juan José Biotechnology Genetic engineering transgenic animals recombinant proteins Biotecnología Ingeniería Genética animales transgénicos proteínas recombinantes The use of transgenic animals for the production of recombinant proteins for therapeutic purposes has been an alternative used for the production of drugs. The ability to make complex post-translational modifications in an efficient manner is an advantage that this type of technology has over the use of other transgenic organisms. For this reason, different transgenic animals (ruminants, rabbits, pigs, birds and insects) have been developed over the years and different systems (milk, egg, blood, urine and seminal fluid) have been studied to obtain recombinant proteins. Each animal and each system has advantages and disadvantages, which should be considered before starting the productive process of the protein of interest. Drugs such as ATryn®, Ruconest® and Kanuma® have already been approved by the FDA for human administration. The future of this type of preparations must be considered, given that there are several therapeutic proteins that are in the research phase or waiting to be approved and commercialized. El uso de animales transgénicos para la producción de proteínas recombinantes con fines terapéuticos ha sido una alternativa utilizada para la producción de medicamentos. La habilidad de realizar complejas modificaciones post traduccionales de una manera eficiente es una ventaja que este tipo de tecnología posee sobre el uso de otros organismos transgénicos. Por esta razón, a lo largo de los años se han desarrollado diferentes animales transgénicos (rumiantes, conejos, cerdos, aves e insectos) y se han estudiado distintos sistemas (leche, huevo, sangre, orina y fluido seminal) para la obtención de proteínas recombinantes. Cada animal y cada sistema cuenta con ventajas y desventajas, las cuales deben ser consideradas antes de comenzar el proceso productivo de la proteína de interés. Medicamentos como el ATryn®, el Ruconest® y el Kanuma® ya han sido aprobados por la FDA para la administración en humanos. El futuro de este tipo de preparados debe ser tomado en consideración, pues existen varias proteínas terapéuticas que se hallan en fase de investigación o a la espera de ser aprobadas y comercializadas. 2019-10-23 2020-09-25T23:12:44Z 2020-09-25T23:12:44Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/4798 10.18845/tm.v32i4.4798 https://hdl.handle.net/2238/12026 spa https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/4798/4568 application/pdf Editorial Tecnológica de Costa Rica (entidad editora) Tecnología en marcha Journal; 2019: Vol. 32 Núm. 4 Octubre-Diciembre; Pág. 133-144 Revista Tecnología en Marcha; 2019: Vol. 32 Núm. 4 Octubre-Diciembre; Pág. 133-144 2215-3241 0379-3982
institution	Tecnológico de Costa Rica
collection	Repositorio TEC
language	Español
topic	Biotechnology Genetic engineering transgenic animals recombinant proteins Biotecnología Ingeniería Genética animales transgénicos proteínas recombinantes
spellingShingle	Biotechnology Genetic engineering transgenic animals recombinant proteins Biotecnología Ingeniería Genética animales transgénicos proteínas recombinantes Alvarado-Madrigal, María Fernanda Chavarría-Quirós, Tannia Leiva-Montero, Brayan Mora-Román, Juan José Recombinant protein production from transgenic animals: Systems and applications
description	The use of transgenic animals for the production of recombinant proteins for therapeutic purposes has been an alternative used for the production of drugs. The ability to make complex post-translational modifications in an efficient manner is an advantage that this type of technology has over the use of other transgenic organisms. For this reason, different transgenic animals (ruminants, rabbits, pigs, birds and insects) have been developed over the years and different systems (milk, egg, blood, urine and seminal fluid) have been studied to obtain recombinant proteins. Each animal and each system has advantages and disadvantages, which should be considered before starting the productive process of the protein of interest. Drugs such as ATryn®, Ruconest® and Kanuma® have already been approved by the FDA for human administration. The future of this type of preparations must be considered, given that there are several therapeutic proteins that are in the research phase or waiting to be approved and commercialized.
format	Artículo
author	Alvarado-Madrigal, María Fernanda Chavarría-Quirós, Tannia Leiva-Montero, Brayan Mora-Román, Juan José
author_sort	Alvarado-Madrigal, María Fernanda
title	Recombinant protein production from transgenic animals: Systems and applications
title_short	Recombinant protein production from transgenic animals: Systems and applications
title_full	Recombinant protein production from transgenic animals: Systems and applications
title_fullStr	Recombinant protein production from transgenic animals: Systems and applications
title_full_unstemmed	Recombinant protein production from transgenic animals: Systems and applications
title_sort	recombinant protein production from transgenic animals: systems and applications
publisher	Editorial Tecnológica de Costa Rica (entidad editora)
publishDate	2019
url	https://revistas.tec.ac.cr/index.php/tec_marcha/article/view/4798 https://hdl.handle.net/2238/12026
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score	12.040952

Recombinant protein production from transgenic animals: Systems and applications

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