The present study is based on the experiences of lives in patients with tuberculosis, since it is a problem of great magnitude, it also considers a public health problem due to the increase of morbidity and mortality rates in the region. The current investigation was carried out with the objective of knowing the life experience in patients with tuberculosis attending the Nicolás A. Solano Hospital. In this order of ideas, the study is based on qualitative field research, non-experimental design and phenomenological descriptive level. The population is conformed by the patients with tuberculosis that attend the consultation of medicine, and as for the participants, it was represented by six (6) patients; in this sense, the sample was intentional. The technique corresponded to the in-depth interview. In continuity, the methodological aspects of the study maintained the criteria of scientific rigor, together with the criteria of validity, under the application of conventional criteria and application of own criteria. In emphasis, the research obtained as a result that because the disease is contagious the patient must take care not to infect others, the disease has changed the patient's life due to isolation and treatment. The investigation concluded, that by virtue of the degree of imbalance that the tuberculosis disease generates in the organism, given the need for changes, causing long-term isolation for the rehabilitation of the patient, thus promoting involuntary detachment and the lack of family communication.