Today as yesterday. Parabiosis and its combination with other techniques in order to unlock the secrets of the blood.

This paper reviews a few important discoveries related to exercise physiology, made possible by the parabiosis model. Parabiosis is an experimental physiological setup in which two animals share a common blood circulation. By means of this approach it is possible to demonstrate the existence of circ...

Descripción completa

Autor Principal: López Dávila, Alfredo Jesús
Formato: Artículo
Idioma: Español
Publicado: Escuela de Educación Física y Deportes - Universidad de Costa Rica 2014
Acceso en línea: http://revistas.ucr.ac.cr/index.php/pem/article/view/11073
http://hdl.handle.net/10669/21728
Sumario: This paper reviews a few important discoveries related to exercise physiology, made possible by the parabiosis model. Parabiosis is an experimental physiological setup in which two animals share a common blood circulation. By means of this approach it is possible to demonstrate the existence of circulating blood factors as well as their effect on several organs. Although parabiosis has been performed for over 150 years, it is at the present time often performed because its combination with modern methods provided by advances in molecular biology makes it much stronger. Using parabiosis, it has been shown that circulating blood factors in animals are capable –among other actions- of a) controlling body fat mass by means of negative feedback b) bringing down ageing-related cardiac hypertrophy and its associated diastolic dysfunction c) inhibiting neurogenesis in the dentate gyrus of the hippocampus and impairing cognitive functions d) enhancing remyelination in the spinal cord and e) enhancing or inhibiting regeneration of skeletal muscle after injury. The continuous finding of circulating blood factors and their effect on several organs raises new questions about the cellular and molecular mechanisms explaining such phenomena and its application to human health. Exercise physiology is a valuable tool in order to find the answers.