Oxytetracycline and Gentamicin: Two Clinicallyrelevant Antimicrobials Widely Used by Costa Rican Farmers. Implications of Their Use Outside Clinical Cettings and Request for Action

This mini-review deals with oxytetracycline and gentamicin: two clinically-relevant antimicrobials that find extensive usage in horticulture and other productive activities. The manuscript begins with a few words on their mechanism of action and clinical utility. Thereafter I address the most import...

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Autor Principal: Rodríguez Sánchez, César
Formato: Artículo
Idioma: Inglés
Publicado: 2015
Acceso en línea: http://revistas.ucr.ac.cr/index.php/medica/article/view/7848
http://hdl.handle.net/10669/12365
Sumario: This mini-review deals with oxytetracycline and gentamicin: two clinically-relevant antimicrobials that find extensive usage in horticulture and other productive activities. The manuscript begins with a few words on their mechanism of action and clinical utility. Thereafter I address the most important mechanisms of acquired or intrinsic resistance described to date and some implications of the unrestricted use of these drugs outside clinical settings. A number of reports on the occurrence of antimicrobial-resistance genes and antimicrobial-resistant bacteria in agroecosystems illustrates that a threat exists and justifies the plea for monitoring programs and environmental risk assessments with which the article concludes.